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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

我们希望看到的亚太地区是一个稳定、有秩序的地区,是一个可以协商一致、达成原则的地区,是一个有能力管控分歧的地区,也是一个有智慧解决争端的地区。
印度总理纳伦德拉莫迪(Narendra Modi)会尝试更多非正统的经济试验吗?

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

失业率减幅在2015年的下降得可能不会那样的迅速,据经济学家所言,特别是如果更多的人进入劳动力市场由于更容易找到工作。尽管如此和2014年相似的大量招聘和录用将会使低的失业率数据显得更加的可信。
The report also found that the top cities in intellectual capital and innovation and technological readiness also achieved high scores in the overall ranking, a clear indication that technologically advanced cities were more likely to earn the title of "cities of opportunity".

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

After months have passed without a culprit in her daughter's murder case, Mildred Hayesmakes a bold move, painting three signs leading into her town with a controversial message directed at William Willoughby, the town's revered chief of police. When his second-in-command Officer Dixon, an immature mother's boy with a penchant for violence, gets involved, the battle between Mildred and Ebbing's law enforcement is only exacerbated.

Graphical abstract: Soft matter science and the COVID-19 pandemic
From the themed collection: 去年全国300城土地收入破4万亿
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Amazon joins the innovators list for the first time for innovations in data centers, devices, electronic methods and systems, according to its latest report.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

2013 Rank: 12
当地媒体上周三报道,中国西南部重庆市的一名学生因嫌同学上课吵闹而试图下毒,被判有期徒刑一年。
You might think 60% is absolutely nothing, but this is a significant step, seeing as gay marriage was not legal anywhere in the United States in 2003.
Inflation (and deflation) won't rear its ugly head Surging oil production — along with slower global growth — has caused the price of petroleum to collapse from more than $100 a barrel last summer to barely $50 a barrel at the end of 2014. The effect has been to reverse an uptick in U.S. inflation earlier in the year.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

Plum Alley:
con全部+fid相信+ent表示形容词,“…的”→自信的
If audiences didn’t yet know the film was set in the early 1980s, one look at Anna’s straight bangs confirms it. The rest of her shoulder-length hair forms a slight curved frame around her face. It’s a simple look, but a powerful one for this woman, whose husband, Abel (Oscar Isaac), runs a heating oil business, but whose past is a little more complicated.
还是说回TextPride吧。雷和欧布莱恩发现,用户很喜欢各种品牌授权的表情符号,他们相信广告主肯定希望非常便捷地通过一家供应商来进入多种短信应用。但他们也明白,这充其量只能占到这项业务的一半份额。对运动队这类大名鼎鼎的品牌来说,用户是愿意为这些贴纸埋单的。但那些不知名的品牌就需要自己掏钱来挤进这个圈子了。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Though bionic legs are of course a huge boon to amputees, they lack actual nerve connections with the body. As a result, walking on them is cumbersome and tiring. But last year, Seattle resident Zac Vawter was outfitted with the world's first thought-controlled leg, a bionic limb that takes signals directly from his mind.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

In the heart of Wan Chai, on one of Hong Kong’s busiest streets, stands a 33-storey office tower that earlier this year became the second most expensive property to change hands in a city that boasts the world’s costliest property market.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

The Thomson Reuters Top 100 global innovators program identifies innovators annually through an in-depth analysis based on a series of patent-related metrics that analyze what it means to be truly innovative.
strengthen

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

The joint programme delivered by IQS of Spain, Fu Jen Catholic University in Taiwan and the University of San Francisco saw the biggest rise. Its Master in Global Entrepreneurship Management jumps 34 places to 43rd, making up for a drop of 19 places the previous year. The only programme to be delivered on three continents, it is ranked top for international course experience.
Only two people know the Oscars winners list and supervise the counting procedures - PwC tax adviser Martha Ruiz and Brian Cullinan an accountant.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

For all of the acceptance speech kerfuffle when Gwyneth Paltrow won best actress for her role as Viola de Lesseps in John Madden’s 1998 film Shakespeare in Love, the Hollywood star has since said she keeps the award tucked away – “the thing freaks me out”.
We learned that animals may make choices based on aesthetics.

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 北京:疏解企业将享多重激励
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

The banks' ability to return money to shareholders have declined. The slowing earning growth, high nonperforming loans and required deposits on the reserve have placed pressure on the banks in regards to capital supplement, said Guo Tianyong, director of the China Banking Research Center at the Central University of Finance and Economics.
但与其他世界主要国家领导人相比,这薪酬已经是最高了。
Others who made the top ten include Amazon's Jeff Bezos at fifth on the list, Mark Zuckerberg of Facebook at sixth, Oracle's Larry Ellison at seventh, Michael Bloomberg at eighth, and tied for ninth are David and Charles Koch.
他说:“目前为止,健身追踪器还不属于这类产品。但是下一代可穿戴设备有潜力跨越这个至关重要的里程碑。”

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

Wages will finally accelerate after years of stagnation

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

23% of wealthy Chinese women work in real estate and 18% of them are involved in finance and investment, followed by manufacturing accounting for 14%.
卓越雇主排名:11

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

8. Pour-Protection by Pet Life

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Bobbi's dad Anton, 28, admits that he had his concerns at first, but is now comfortable with Bobbi's routine.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

? The failure of a backup generator forced the evacuation of the Langone Medical Center, part of NYU hospital. About 200 patients had to be moved. Officials are investigating why the backup power failed.
For newcomers, these changes provide fresh housing options. But for residents, they can spell displacement. The same is true for shops such as De Robertis Pasticceria and Caffe in the East Village, which just closed after a 110-year run. And next year, the Union Square Cafe will likely conclude its 30 years in Union Square.
To be brief, people with type C personalities are perfectionists, consistent and will never break the rules. Unlike their "sister" type A; type C personalities tend to take their time with the details and often check and recheck their work for accuracy. They tend to be deep thinkers and like to know every detail in regards to their work and life.
观看《皮囊之下》再次让我想起另外一个比较:奥逊·威尔斯,成功的用收音机创造了火星入侵的骗局;还有《赝品》(1975)中,那个让他的伙伴奥佳·柯达穿着迷你短裙走在街上,然后偷偷拍摄那些男人们看她的淫荡表情。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

3. Learn from others.
5. Hong Kong, China-A junk boat set against the famous skyline might be the iconic shot of Hong Kong, but Lonely Planet picked the territory for its natural heritage miles away from Victoria Harbor.
人们大多认为,中国的智能手机只会越来越便宜。与此相反,她援引一些研究结果,表明去年中国智能手机的平均售价趋于稳定。同时随着中国用户开始购买品质更好的智能手机,售价实际上已开始走高。
It’s no surprise that credit is “pro-cyclical.” When asset prices are booming, optimistic lenders tend to make more loans and often feed the euphoria. When markets sink, lenders rein in risk and sometimes make the downturn worse.
吉尔伯特表示,对可穿戴设备的不断试验十分重要,但是现在短期内,人们还需要探讨一下:“技术的演进以及企业的研发力量共同推动了现有可穿戴产品的发展,但它们是否真的能够满足用户的需求;各公司又是否需要探索不同的合作模式,让可穿戴设备不仅限于早期使用者的圈子,而是被主流人群所接受”。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

If you are a working-class white person and you fear that the new, cosmopolitan world will destroy or diminish an identity you cherish, you have no culturally acceptable way to articulate what you perceive as a crisis.
projected

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Jiang Yiyi at the China Tourism Academy suggests China adopt a long-term national plan to improve the country's image and investment in inbound tourism to attract more visitors.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

China will remain an important engine for world growth amid sluggish global economic recovery.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

威尼斯被普遍认为是世界上最浪漫的城市之一,也是许多游客必来的水上城市。
发脾气大奖
The untitled movie revolves around two intersecting love triangles, obsession and betrayal, set against the music scene. It stars Christian Bale, Cate Blanchett, Michael Fassbender, Ryan Gosling, Rooney Mara and Natalie Portman.
从1970年到今天,世界各地的文盲减少了50%。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

extra出+vag走…走过头…奢侈+ant表形容词,“ …的”→奢侈的
玛戈特·瓦尔斯特伦在20多岁时结束了一段充满暴力的感情。作为外交部长,她正在一个传统上属于男性的领域里挑战各种假定。
The reality turned out to be tougher than he imagined. “I saw it as a two-year opportunity,” says Mr Ravenscroft. “The grinding reality is that it’s a slog.” Moreover, his mentor worked at Lehman Brothers, the bank that collapsed in 2008. “It wasn’t quite as long a mentoring relationship as I’d hoped,” he laughs.
《请以你的名字呼唤我》

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

李亦表示:“贫困阻碍了网民数量的进一步增加,使得网民数量占全部人口的比例只在50%左右。”
伦敦商学院在所有这4项排名上表现强劲,包括全日制MBA课程排名第一,合办EMBA(与美国哥伦比亚商学院(Columbia Business School)合办)和定制高管教育课程均排名第三。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Dershowitz said this guidance was too vague to provide students with any real understanding of the school's expectations. "When you punish a student seriously without articulating standards, I think it raises questions," he said.
剑桥大学佳奇管理学院也以优异表现结束今年,它首次出现在开放招生和定制高管教育榜单上,而且在MBA榜单上的排名上升3位,在EMBA榜单上的排名上升12位。
“能自己当老板,经营自己的公司,我感到很骄傲,”凯蒂在刚过去的夏天对福布斯100位名人封面故事说,“我是一名企业家,并且没有刻意回避这一身份。事实上,我很珍惜自己当老板的体验。”
8.软件工程师
Not until recently anyway. But scientists at Weill Cornell Medical College have at last managed to—at least with mice and monkeys. This produced artificial retinas, whose chips convert images into electronic signals and whose tiny projectors convert electronic signals into light.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

10、《星球大战:侠盗一号》
Google
全世界的目光都在聚焦巴西,因为这个国度将举办最令人期待的两大体育盛事——2014年世界杯足球赛和2016年夏季奥运会。在巴西,你不仅可以观看精彩赛事,为你最喜欢的队伍及运动员欢呼,还可以前往“地球之肺”——亚马逊雨林旅行,体验“与世隔绝,拥抱自然”。不管你如何安排行程,巴西之行必定是一次难忘之旅。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

If you outsource any or all of your content writing, you need to make sure your content is original. Paste content into Copyscape’s analyzer tool, and you’ll instantly know whether the content is original.
2.Yeah, I’ll start working on that ASAP! – Because telling you I have 10 things to do first would just irritate you。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

The number of inbound travelers to Beijing grew after the city hosted the 2008 Olympics until 2012, when it saw a 3.8% decline, followed by the further drop last year.
China is trying to attract more students with an international background because of the country's involvement in global cooperation, said Miao Lü, secretary general of the Center for China and Globalization.
Structural challenges in the market, which is dominated by large property developers, have generally acted as disincentives to large European and US asset managers.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Get Out
Throughout Downsizing, I kept asking myself what the point of all of this was, never engaged by its hodgepodge of themes. I wish the filmmakers had asked that question too.
单词medal 联想记忆:

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: 2015年1-11月防水行业的经济分析
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

A Datafolha polling group survey published in the Folha de S. Paulo newspaper showed that at Saturday's Brazil versus Chile match, 67 percent of attendees classified themselves as white and 90 percent came from Brazil's top two economic classes, which represent about 15 percent of the country's population.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

After working for half a year, the average monthly income for 2014 graduates is RMB3,487, a significant increase from RMB3,250 in 2013 and RMB3,048 in 2012.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

2013年排名:3
众所周知,蝙蝠侠的扮演者不再是克里斯汀·贝尔,而是肉肉的本·阿弗莱克。他将打败超人,拯救哥谭镇。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

'While RMB is on the rise, currencies from some of China's competitors for tourism, such as Japan, are depreciating, meaning travel to some other Asian countries has been getting cheaper while travel to China is becoming more costly,' Jiang Yiyi said.
Succeeding as an entrepreneur takes hard work and persistence because, unfortunately, there is no business-startup fairy who magically bestows success on small businesses and their owners.
贴一些小便条来激励自己。一个美好的办公环境,还需要一些能够让自己提神的小纸条。
位居榜单第三的是史蒂夫·卡瑞尔(Steve Carell)。《卑鄙的我2》(Despicable Me 2)在今年大获成功,斩获票房9.19亿美元。该电影系列累计已取得14亿美元的全球票房,该系列第三部《小黄人》(Minions)也即将上映。卡瑞尔今年还出演了小制作独立影片《迷途知返》(The Way Way Back)和《超级魔术师》(The Incredible Burt Wonderstone)。后一部影片的票房虽未能赚回制作成本,但是我们这里只关注票房收入——该部影片为卡瑞尔2013年的电影票房收入又添2,250万美元。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

TWO Americans were awarded the Nobel economics prize yesterday for studies on the matchmaking taking place when doctors are coupled up with hospitals, students with schools and human organs with transplant recipients.
Last week, Lu was appointed director of the office for Beijing's Leading Group of Promoting Beijing-Tianjin-Hebei Integration Development, a move to accelerate Beijing's moves to coordinate with Tianjin and Hebei province.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

如果你觉得现在的杜兰特骨瘦如柴,那你得瞧瞧他在蒙特罗斯基督教会学校时的瘦弱身板。
An Obama tweet, published in August after racial violence rocked Charlottesville, Virginia was the second most-shared this year, according to Twitter, with more than 1.7 million retweets.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

一位毕业生表示:“伦敦商学院拓宽了我的专业视野,开启了国际职业机遇。”他补充称:“在毕业后的3年里,我在美国、加拿大和香港工作过,辗转于公司银行业务、债务资本市场等多个领域。”

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
From the themed collection: 水泥行业推进兼并重组的实施意见
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

《银河护卫队》之所以能成为一部大获成功的超级英雄系列电影,原因之一就是它的幽默感。这部影片充满了自嘲和讽刺。观看这部影片的时候,你不会一直笑个不停,但至少会有一些瞬间让你哈哈大笑,比如树人和克里斯?帕特出场的时候。
美国电影学会选出了十部本年度最佳电影和电视剧。这些影片排名按字母表顺序排列,美国电影学院评审团选出这些影片的标准是促进了活动图像的艺术化、提升了美国艺术形式文化遗产的魅力、对观众和艺术者有所启发、在美国社会上占有一席之地。
jewelry
The former Miss Israel, Gal Gadot spot 6th in the list of 10 most beautiful women of 2015. She is the leading fashion model for the clothing company Castro. Gadot is known for her role as Gisele Yashar in The Fast and the Furious film series.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

When he was offered the role of "Will" on Fresh Prince, he had 70% of his wages garnished for the first three seasons. After three years, he was able to take home his full salary. Basically, the first line of the theme song could have been written about Will Smith's real life: "This is a story all about how/My life got flip-turned upside down." Except in real life, the "guys making trouble in his neighborhood" was the IRS.
3月5日,第十二届全国人民代表大会第四次会议在人民大会堂举行开幕会,国务院总理李克强作政府工作报告。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

艾伦是一名优秀的喜剧演员并凭借自2003年起主持由她自己名字命名的脱口秀节目而被观众喜爱熟知。
在《渴望生活》这张专辑的第一首歌《爱》中,拉娜·德雷唱着“过去的一切造就了今天的你,但未来由你决定”。
电子商务巨头亚马逊首次进入汤森路透2015年全球创新百强名单,而世界上最大科技服务公司IBM却未能上榜。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

infinite
The surviving cat, since named Trooper, has recovered and found a new home.
China had a full-year GDP target of “around 6.5 per cent” for 2017.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

凡是这家汽车服务公司的忠实员工在效力满10年后,都可获得一份奖励:在佛罗里达州波卡拉顿的一处度假胜地欢度周末(此地距该公司总部仅15分钟车程)。这项福利此后每5年都可以享受一次。
我是否在维持健康的人际关系?在你的生活中,是否有一段关系需要你额外的关注?你是否需要给某人平反?在如何对待他人这个问题上,努力保持清醒的头脑。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

This year, China will further enhance international cooperation in fighting corruption, said a statement adopted at the second plenary session of the 19th CPC Central Commission for Discipline Inspection.
In New York it is illegal for anyone to rent out a room in an apartment in a multifamily building for less than 30 days if a tenant is not present. Yet almost weekly, someone writes to Ask Real Estate seeking advice on how to skirt the rules. What if I swap apartments? What if nothing is in writing?
The data was released by the National Bureau of Statistics on its website, saying the growth rate rebounded for the first time after a four-year straight drop.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
From the themed collection: 中国石材行业上演“三国演义”
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

repertoire
China's movie box office revenue grew 9 percent to $8.9 billion (RMB 60.98 billion) in 2018.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

将第1题到第9题的分数相加,计算自己在“消极情感”维度的得分。
WTF.3: I'm Bigger Than You Think
adj. 优雅的,精美的,俊美的

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

For Maddie Ziegler, from Pennsylvania, life couldn't be more different.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Of the graduates to have been through the scheme, 42 per cent have not persisted with teaching. But Teach First says even those who have left the profession remain loyal to the programme’s values.
However, before starting their EMBAs, there is already a wide gap in salaries, with women earning on average 15 per cent less than men, at $111,000 and $128,000 respectively.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Not every band can sound fresh 40 years into a career, but not every band is Blondie.
6.You Spend Time Looking For Other Jobs

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

Volatility in currency markets is also likely to be a factor for agricultural commodity prices in the next 12 months, with the euro likely to depreciate as a result of French, Dutch and German elections, Rabobank reckons.
Company: Samasource

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
From the themed collection: 瓷砖石材新品夺眼球
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

Columbia Pictures克里斯蒂安?贝尔、艾米?亚当斯和布莱德利?库珀在电影《美国骗局》中早在1月份闹片荒的时候,人们不会想到今年会迎来如此多好电影。不仅如此,有几部影片甚至达到了被我们在心目中理想化了的那些老电影的水准。今年有两部电影脱颍而出。纯娱乐片方面,赢家显然是《美国骗局》(American Hustle),这部由大卫?欧?拉塞尔(David O. Russell)执导的影片讲述了上个世纪七十年代的行骗高手和他们的微妙骗术的故事,幽默诙谐,令人捧腹。而从创新角度看,《地心引力》(Gravity)的全新拍摄技术给观众带来了新的观影体验。人们普遍认为《美国骗局》无可挑剔,这部疯狂喜剧片是一部时代佳作。我个人则认为,《地心引力》是今年的最佳影片。
无论从哪个角度看,2014年都是本田汽车公司宁愿忘却或掩盖的一年,看看本田为2015年提出的宏大口号——“本田之年”就知道了。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Common 和 Day 将会演绎电影《马歇尔》中的歌曲《Stand Up For Something》还有Settle会演唱电影《马戏之王》中的歌曲《Thisis me》。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

我曾被一位CEO要求雇用一位有着乌黑长发的长腿美眉,虽然她的能力不强。还有一次,我被要求不要雇用有小孩的应聘者,因为公司已经雇用了太多为了看足球赛请假的员工。这种事经常发生。
无论你相信与否,今年的搞笑文学奖被授予美国政府审计总署(GAO),以表彰他们发表的有关如何准备一份报告的报告的报告的报告……
但同比而言,厦门涨幅为43.9%,排在第二位,仅落后于安徽省会合肥,后者为47.6%。65个城市同比上涨,5个城市同比下跌,这表明虽然房价可能不会像以前一样迅速攀升,但上涨仍然具有普遍性而且较有韧性。
The next step? Jalava plans to upgrade the finger with an RFID tag and add wireless support. He also wants to add more memory, which seems pointless to us. If he needs more storage, he has nine other fingers he can chop off and replace with flash drives.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

为什么小皇帝詹姆斯不在双头肌和肩膀上再带那些奇怪的饰物,对此我很好奇。当然,我敢打赌他不会再带那些东西——因为它们没啥用处。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

妮妮·切利(Neneh Cherry),《空白计划》(Blank Project), Smalltown Supersound
Alice Schwarzer
SETTING: This house is in Kenwood, a neighborhood of 19th- and 20th-century Tudors, Mediterraneans, Victorians and colonial-style houses between Cedar Lake and Lake of the Isles, in the city’s Chain of Lakes. Roads are curving; sidewalks are lined with maple and ash trees. According to the listing agent, many of the neighborhood’s older houses have been restored, while houses built within the last 30 years have been torn down and replaced.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

这两笔交易中最大的风险在于伊巴卡和塔克这个夏天即将成为自由球员,但是失去一到两名球员的痛苦和早早的在五月就被淘汰出季后赛相比就不算什么了。
不是每个乐队都能在四十年的职业生涯中始终给人以清新的感觉,然而并非每个乐队都是金发女郎。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

Hunger Games star Jennifer Lawrence on Tuesday topped a Forbes magazine list of the world’s highest-paid actress for the second straight year, earning some $46 million, followed by Melissa McCarthy.
Foss 还指出别人的推荐信有时间标记。如果你一周之内有五个新的赞那样看起来会很可疑,这些赞不像是真心的,好像你在刷好评,让别人说你好。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
From the themed collection: 检方揭秘让“黑中介” 无所遁形
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

It was Somerset Maugham who said the French Riviera is “a sunny place for shady people” – and looking around at all the 'models' in the hotel lobbies and the men in dark sunglasses who seemed to know them, I knew what he meant. Behind the festival's shiny facade, there is an unseemly side – and beneath the azure waters, a polluted mess. The French diver and environmentalist Laurent Lombard's video of the Cannes seabed strewn with waste and debris went viral before the festival began. We were assured there was no danger to swimmers, and the mayor had it cleaned up according to the Daily Mail – but the Med had certainly lost some of its sparkle.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

当你走进来的时候,我对你的认识比你的想象中的多。我在网上寻找关于你的资料,利用我自己的关系网来做面试前的背景调查。
世界各国同意将地球升温控制在3.6华氏度以内,这需要在未来大约30年里,抑制温室气体排放,之后基本停止排放。科学家表示,如果在本世纪,排放量继续按照当前趋势发展,地球温度将比前工业化时代水平提高10华氏度,那将与人类文明当前的形式不再兼容。
近年来,大多数发达国家的排放量一直在逐步下降,这部分是因为不景气的经济形势,同时也是因为日益加强的气候政策。2013年,由28个国家组成的欧洲联盟(European Union)的排放量下降了1.8%,虽然德国和波兰等几个国家的耗煤量出现增加。英国、意大利和西班牙的排放量显著下降。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
From the themed collection: 湖北省启动商品房销售检查
Paper

Length-scale dependence of protein hydration-shell density

It was visible, for example, on many of Frida Giannini’s Gucci runways, including the tablecloth shades and A-line shapes of leathers for autumn-winter 2014; the pastel tunics and ruffled hostess dresses of spring-summer 2013; the bright Beatle trouser suits and caftans of spring-summer 2009.
“People claim he has a cool exterior but he’s a very passionate guy and he stands up for what he believes in,” says Bob Iger, Walt Disney chief executive and Apple board member since 2011. “That is in both his personal life and at Apple.”
The ministry said that it had no tolerance for cheating and had asked public security departments to conduct an investigation.
不过,在这一反弹中也出现了奖金数额的下滑:去年的平均年终奖是12821元人民币(合1861美元),比2015年多了大约2000元人民币,却仍比2014年的平均值少了800元人民币。在奖金缩水的被调查者中,逾四分之一的人将原因归结为公司业绩太差。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

“How you leave a position can make a lasting impression,” notes OfficeTeam executive director Robert Hosking. That’s for sure. Most (86%) of the HR managers in the survey said that how someone quits a job “affects their future career opportunities.” Word gets around.
支持:影片演技大获好评,尤其是故事的主人公——那些孩子们,以及旅馆经理的扮演者威廉达福。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Although various public incentives exist, many come in the form of tax breaks, low-interest loans or rebates. So a building might have to levy an assessment or raise maintenance to cover initial costs. “You run into the problem of nobody giving you the money upfront,” Mr. Luxemburg said.
The capital plans to move most of its municipal departments to the suburban district of Tongzhou in 2017, the Beijing Municipal Committee announced on Wednesday.
n. 释放,让渡,发行

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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Complying with the law may prove challenging, even if improvements ultimately reduce long-term costs. In addition, 2015 is the deadline for buildings to convert from No. 6 heating oil to No. 4 oil, which is less polluting.
SIZE: 5,003 square feet total

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